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A sticky solution to protein-selective sugar installation

Matthew R. Pratt

Department of Chemistry, University of Southern California, Los Angeles, CA, USA
* Correspondence: Matthew R. Pratt(matthew.pratt@usc.edu)

O-GlcNAc is a widespread form of intracellular glycosylation that is added to thousands of substrates by one enzyme, O-GlcNAc transferase (OGT), and removed by one other enzyme, O-GlcNAcase (OGA); the generality of this biochemistry has made it extremely challenging to alter the levels of O-GlcNAc on selected proteins to investigate the consequences of specific modifications. In a recent Cell paper, Zhu et al. develop an RNA aptamer-based strategy to localize endogenous OGT to endogenous proteins of interest, resulting in increased O-GlcNAc modification.

https://doi.org/10.1038/s41422-023-00787-2

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