Advanced Search

Submit Manuscript

ADVANCE ONLINE PUBLICATION

LETTERS TO THE EDITOR

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

* Correspondence: 0

Dear Editor,

Pseudomonas aeruginosa is a ubiquitous Gram-negative opportunistic bacterium that notoriously causes infections with a high mortality rate in hospitalized patients, especially those with compromised immune systems.1 P. aeruginosa can cause acute infections that are typically associated with the cytotoxins secreted by the type III secretion system (T3SS),2 as well as chronic persistence that relies on type VI secretion system (T6SS) and biofilm formation, including those in cystic fibrosis patients.3 An intercellular communication network based on cell density, quorum sensing (QS), regulates numerous gene expressions including those related to both acute and chronic virulence of P. aeruginosa.4 The global regulatory protein of the repressor of secondary metabolites (Rsm) system in bacteria, RsmA, is found to predominantly regulate these virulence entities in P. aeruginosa by modulating related gene expressions at transcriptional and posttranscriptional levels.https://doi.org/10.1038/s41422-023-00786-3

FULL TEXT | PDF

Browse 220