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Repurposing FBP1: dephosphorylating IκBα to suppress NFκB

Gang Zhang¹ , Jingjing Tao² , Liming Lin² , Wensheng Qiu^1,* , Zhimin Lu^2,3,*

¹Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong, China
²Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
³Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China
* Correspondence: Wensheng Qiu(wsqiuqd@163.com)Zhimin Lu(zhiminlu@zju.edu.cn)

Metabolic enzymes can function as protein kinases and protein phosphatases to govern the phosphorylation status of protein substrates, thereby regulating pivotal cellular activities. A new study published in Cell Research demonstrated that fructose 1,6-bisphosphatase 1 directly dephosphorylates IκBα to suppress NFκB activation and modulate the tumor immune microenvironment.

https://doi.org/10.1038/s41422-023-00785-4

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