Advanced Search
Submit ManuscriptADVANCE ONLINE PUBLICATION
Transgenerational inheritance of engineered cytosine methylation in mice
Maximilian M. L. Knott , Oded Rechavi
Department of Neurobiology, George S. Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, IsraelThe occurrence of transgenerational epigenetic inheritance has overwhelming evidence in plants and invertebrates; however, the substantial erasure of DNA and histone modifications during early embryogenesis has been considered an insurmountable barrier to the transmission of epigenetic information in mammals. In a recent issue of Cell, Takahashi et al. demonstrate that engineered DNA methylation states of promoter-associated CpG islands can be inherited for multiple generations in mice.
https://doi.org/10.1038/s41422-023-00799-y