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Hematopoietic heterogeneity starts at the hemogenic endothelium

Eline Lemerle , Eirini Trompouki

IRCAN Institute for Research on Cancer and Aging, INSERM Unité 1081, CNRS UMR 7284, Université Côte d’Azur, Nice, France
* Correspondence: Eirini Trompouki(etrompouki@unice.fr)

Hematopoietic stem cells are heterogenous during development and adulthood; however, when and how this heterogeneity begins is still not well understood. In a new study published in Cell Research, Xia et al. show that hemogenic endothelial cells are heterogeneous and the transcription factor SPI1 in mammals or Spi2 in zebrafish is partially responsible for the establishment of this heterogeneity.

https://doi.org/10.1038/s41422-023-00806-2

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