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Identity revealed for a long-sought ER anion channel

Laura Bianchi

Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL, USA
* Correspondence: Laura Bianchi(lbianchi@med.miami.edu)

Ca2+ release from the endoplasmic reticulum (ER) requires flux of counterions. In a recent paper published in Cell Research, Guo and colleagues, using a powerful combinatorial approach, show that CLCC1 is the long-sought mediator of Cl– efflux from the ER that counteracts Ca2+ release and that its loss causes ER stress and contributes to ALS pathology.

https://doi.org/10.1038/s41422-023-00807-1

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