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Atypical bacterial Argonautes regulate antiphage defense

Arpita Chakravarti , Dinshaw J. Patel

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
* Correspondence: Arpita Chakravarti(chakraa2@mskcc.org)Dinshaw J. Patel(pateld@mskcc.org)

Unusual Argonaute (Ago) proteins have been recently identified in prokaryotic immune systems, which upon binding to foreign nucleic acids, activate their associated NADase effectors. Recent cryo-EM structures of such unique Ago-associated TIR and SIR2 NADases revealed an unconventional nucleic acid binding-mediated NADase activation, adding to the repertoire of canonical cyclic second messenger-driven TIR and SIR2 activation mechanisms.

https://doi.org/10.1038/s41422-023-00862-8

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