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Structural insights into asymmetric activation of the calcium-sensing receptor–Gq complex

Shenglong Ling^1,† , Xianyu Meng^1,† , Yuan Zhang¹ , Zhemin Xia¹ , Yingxin Zhou¹ , Fan Yang^1,* , Pan Shi^1,* , Chaowei Shi^1,* , Changlin Tian^1,2,3,4,*

¹Department of Endocrinology, Institute of Endocrine and Metabolic Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Joint Center for Biological Analytical Chemistry, Anhui Engineering Laboratory of Peptide Drug, Anhui Laboratory of Advanced Photonic Science and Technology, University of Science and Technology of China, Hefei, Anhui, China
²The Anhui Provincial Key Laboratory of High Magnetic Resonance Image, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, China
³Beijing Life Science Academy, Beijing, China
⁴School of Biomedical Engineering, Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, Jiangsu, China
^†These authors contributed equally: Shenglong Ling, Xianyu Meng
* Correspondence: Fan Yang(lsl924@ustc.edu.cn)Pan Shi(shipan@ustc.edu.cn)Chaowei Shi(scwei@ustc.edu.cn)Changlin Tian(cltian@ustc.edu.cn)

https://doi.org/10.1038/s41422-023-00892-2

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