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A precision counterstrike on central nervous system autoimmunity

Aimee S. Payne^1,* , Sangwook Oh²

¹Department of Dermatology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA
²Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea
* Correspondence: Aimee S. Payne(asp2261@cumc.columbia.edu)

Autoantibodies targeting the N-methyl-D-aspartate receptor (NMDAR) induce debilitating neuropsychiatric symptoms and potentially fatal complications due to brain swelling and autonomic instability, requiring aggressive treatments to eliminate the autoreactive B-cells and autoantibodies causing disease. In a recent Cell paper, Reincke et al. genetically engineer T-cells to express an autoantigen-based chimeric autoantibody receptor (CAAR) to direct T-cell cytotoxicity specifically against anti-NMDAR B-cells, establishing the basis for a novel precision cellular immunotherapy for NMDAR encephalitis.

https://doi.org/10.1038/s41422-023-00907-y

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