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Chromatin compartments at DNA double-stranded breaks

Jaewon Min^1,2,3 , Jean Gautier^1,3,4,*

¹Institute for Cancer Genetics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA
²Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeon, New York, NY, USA
³Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA
⁴Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeon, New York, NY, USA
* Correspondence: Jean Gautier(JG130@cumc.columbia.edu)

In a recent article published in Nature, Arnould and colleagues reveal that DNA double-stranded breaks (DSBs) strengthen chromatin compartmentalization near the breaks. They show that “D” compartments arise from clustering of Topologically Associated Domains harboring DSBs to facilitate the expression of R-loop-rich genes involved in DSB repair, thereby aiding in their efficient repair at the expense of specific chromosome translocations.

https://doi.org/10.1038/s41422-023-00912-1

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