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Amino acid availability governs mTOR ubiquitination

Xiaoming Dai , Peiqiang Yan , Wenyi Wei

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
* Correspondence: Xiaoming Dai(xdai1@bidmc.harvard.edu)Wenyi Wei(wwei2@bidmc.harvard.edu)

How mTORC1, a master regulator of cell growth, senses amino acid availability to regulate cell growth is an intriguing but mysterious question. In a recent paper published in Cell Metabolism, Ge et al. report that amino acid depletion promotes K27-linked poly-ubiquitination of mTOR through activating a novel tRNA-GCN2-FBXO22 signaling axis to suppress mTORC1 kinase activity.

https://doi.org/10.1038/s41422-023-00910-3

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