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RESEARCH HIGHLIGHTS

Decoding T cell state-specific regulomes in cancer

Giulia Escobar1,2 , Ana C. Anderson3,4,*

1Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
2Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
3Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
4The Gene Lay Institute of Immunology and Inflammation, Boston, MA, USA
* Correspondence: Ana C. Anderson(acanderson@bwh.harvard.edu)

Tumor-infiltrating CD8 T cells comprise a spectrum of differentiation states associated with distinct functional, transcriptional, and epigenetic features; understanding the gene networks regulating each state holds the potential to redirect CD8 T cell functionality towards therapeutically relevant states. In a recent Nature paper, Zhou et al. performed a single-cell CRISPR knock-out screen of 180 transcription factors in tumor-infiltrating CD8 T cells, identifying factors that regulate cell state transitions and represent therapeutically actionable targets.

https://doi.org/10.1038/s41422-024-00926-3

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