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Decoding T cell state-specific regulomes in cancer

Giulia Escobar^1,2 , Ana C. Anderson^3,4,*

¹Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
²Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
³Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
⁴The Gene Lay Institute of Immunology and Inflammation, Boston, MA, USA
* Correspondence: Ana C. Anderson(acanderson@bwh.harvard.edu)

Tumor-infiltrating CD8 T cells comprise a spectrum of differentiation states associated with distinct functional, transcriptional, and epigenetic features; understanding the gene networks regulating each state holds the potential to redirect CD8 T cell functionality towards therapeutically relevant states. In a recent Nature paper, Zhou et al. performed a single-cell CRISPR knock-out screen of 180 transcription factors in tumor-infiltrating CD8 T cells, identifying factors that regulate cell state transitions and represent therapeutically actionable targets.

https://doi.org/10.1038/s41422-024-00926-3

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