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The hidden face of GluD1 at inhibitory synapses

Masayuki Itoh , Michisuke Yuzaki

Department of Neurophysiology, Keio University School of Medicine, Tokyo, Japan
* Correspondence: Michisuke Yuzaki(myuzaki@keio.jp)

The δ-glutamate receptor (GluD), comprising GluD1 and GluD2, is a member of the ionotropic glutamate receptor family, playing a pivotal role in the development and maturation of both excitatory and inhibitory synapses. In a recent study in Science, Piot et al. revealed that GABA, as well as D-Ser, binds to GluD1 to regulate long-term plasticity at inhibitory synapses in the hippocampus, revealing yet another face of GluD receptors.

https://doi.org/10.1038/s41422-024-00931-6

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