Advanced Search

Submit Manuscript

ADVANCE ONLINE PUBLICATION

RESEARCH HIGHLIGHTS

Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection

Hergen Spits1,* , Jenny Mjösberg2,3

1Department of Experimental Immunology of Amsterdam UMC, Amsterdam Institute for Immunology and Infectious Diseases, Cancer Center Amsterdam, Amsterdam, The Netherlands
2Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
3Clinical Lung and Allergy Research Unit, Department of Medicine Huddinge, Karolinska Institutet, Medical unit for Lung and Allergy Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden
* Correspondence: Hergen Spits(Hergen.spits@amsterdamumc.nl)

Group 2 innate lymphoid cells (ILC2s), known for their role in defending against parasites and regulating tissue homeostasis through cytokine secretion, were found to have a new function. Research in Cell shows that, when cultivated in a lab, human ILC2s can target and destroy tumor cells in a living organism using various cell death mechanisms.

https://doi.org/10.1038/s41422-024-00937-0

FULL TEXT | PDF

Browse 157