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T follicular regulatory cells keep B cell-directed autoreactivity in check

Filipa Ribeiro , Luis Graca

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
* Correspondence: Luis Graca(lgraca@medicina.ulisboa.pt)

The immune system well illustrates the need for balance between aggression and tolerance: mechanisms are needed to drive the production of antibodies effective against pathogens whilst preventing the emergence of antibodies targeting our own cells. T follicular regulatory cells can suppress spontaneous antibody-mediated autoimmunity by vetoing B cell-directed reactivity.

https://doi.org/10.1038/s41422-024-00941-4

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