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RESEARCH HIGHLIGHTS

MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis

Manuel Beltrán-Visiedo1 , Siddharth Balachandran2,* , Lorenzo Galluzzi1,3,4

1Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
2Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA
3Sandra and Edward Meyer Cancer Center, New York, NY, USA
4Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
* Correspondence: Siddharth Balachandran(Siddharth.Balachandran@fccc.edu)

Recent data from Cho et al. demonstrate that the DNA repair protein MRE11 liberates CGAS from nucleosomes to license type I interferon secretion upon oncogenic stress and ionizing radiation. MRE11-mediated CGAS activation culminates in ZBP1-driven necroptosis, which is essential for limiting mammary oncogenesis.

https://doi.org/10.1038/s41422-024-00939-y

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