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MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis

Manuel Beltrán-Visiedo¹ , Siddharth Balachandran^2,* , Lorenzo Galluzzi^1,3,4

¹Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
²Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA
³Sandra and Edward Meyer Cancer Center, New York, NY, USA
⁴Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
* Correspondence: Siddharth Balachandran(Siddharth.Balachandran@fccc.edu)

Recent data from Cho et al. demonstrate that the DNA repair protein MRE11 liberates CGAS from nucleosomes to license type I interferon secretion upon oncogenic stress and ionizing radiation. MRE11-mediated CGAS activation culminates in ZBP1-driven necroptosis, which is essential for limiting mammary oncogenesis.

https://doi.org/10.1038/s41422-024-00939-y

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