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Metabolic engineering of the paclitaxel anticancer drug

Audrey Oudin1 , Nicolas Papon2 , Vincent Courdavault1,*

1Biomolécules et Biotechnologies Végétales, BBV, EA2106, Université de Tours, Tours, France
2Univ Angers, Univ Brest, IRF, SFR ICAT, F-49000 Angers, France
* Correspondence: Vincent Courdavault(vincent.courdavault@univ-tours.fr)

In a recently published Science article, Jiang et al. unraveled a couple of missing enzymes achieving key steps in the paclitaxel biosynthetic pathway in yew and reconstituted the production of the main precursor baccatin III in a heterologous host. This advance provides unprecedented perspectives for biotechnological production of this prominent anticancer drug.

https://doi.org/10.1038/s41422-024-00950-3

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