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Immunotherapy for atherosclerosis by targeting pro-inflammatory T cells

Amir Khan , Klaus Ley

Immunology Center of Georgia, Augusta University, Augusta, GA, USA
* Correspondence: Klaus Ley(kley@augusta.edu)

Recent advancements in atherosclerosis management have shifted focus beyond lipid-lowering strategies towards addressing residual inflammatory risks associated with major adverse cardiovascular events. In a recent Cell Research paper, Fan et al. reported that anti-PD-1 monoclonal antibody therapy reduces atherosclerosis plaque size and modulates inflammation by serving as a surrogate PD-1 ligand through interaction with myeloid-expressed Fc gamma receptors.

https://doi.org/10.1038/s41422-024-00955-y

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