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ORIGINAL ARTICLES

Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs

Kuan Ren^1,† , Fengxia Zhou^1,2,† , Fan Zhang^1,†,* , Mingyu Yin^1,† , Yuwei Zhu^1,† , Shouyu Wang^1,† , Yan Chen¹ , Tengjin Huang¹ , Zixuan Wu² , Jiale He² , Anqi Zhang¹ , Changyou Guo¹ , Zhiwei Huang^1,2,3,*

¹HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China
²Westlake Center for Genome Editing, Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China
³New Cornerstone Science Laboratory, Shenzhen, Guangdong, China
^†These authors contributed equally: Kuan Ren, Fengxia Zhou, Fan Zhang, Mingyu Yin, Yuwei Zhu, Shouyu Wang
* Correspondence: Fan Zhang(fanzhang@hit.edu.cn)Zhiwei Huang(huangzhiwei@hit.edu.cn)

CRISPR-Cas systems and IS200/IS605 transposon-associated TnpBs have been utilized for the development of genome editing technologies...

https://doi.org/10.1038/s41422-024-00952-1

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