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APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APP^NL-G-F cerebral organoid model of Alzheimer’s disease

Hang Liu^1,† , Fan Mei^2,†,* , Rongrong Ye^1,3 , Xinyu Han^1,3 , Shudan Wang¹ , Yan Ding¹ , Yun Zhi¹ , Keliang Pang¹ , Wei Guo¹ , Bai Lu^1,4,5,*

¹School of Pharmaceutical Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, China
²Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
³4B Technologies, Limited, Shanghai, China
⁴Beijing Academy of Artificial Intelligence, Beijing, China
⁵Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
^†These authors contributed equally: Hang Liu, Fan Mei
* Correspondence: Fan Mei(meifan@hsc.pku.edu.cn)Bai Lu(bai_lu@tsinghua.edu.cn)

https://doi.org/10.1038/s41422-024-00957-w

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