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APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease

Hang Liu1,† , Fan Mei2,†,* , Rongrong Ye1,3 , Xinyu Han1,3 , Shudan Wang1 , Yan Ding1 , Yun Zhi1 , Keliang Pang1 , Wei Guo1 , Bai Lu1,4,5,*

1School of Pharmaceutical Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, China
2Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
34B Technologies, Limited, Shanghai, China
4Beijing Academy of Artificial Intelligence, Beijing, China
5Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
These authors contributed equally: Hang Liu, Fan Mei
* Correspondence: Fan Mei(meifan@hsc.pku.edu.cn)Bai Lu(bai_lu@tsinghua.edu.cn)

https://doi.org/10.1038/s41422-024-00957-w

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