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Peripheral cancer remodeling of central neural system

Gray Umbach , Shawn L. Hervey-Jumper

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
* Correspondence: Shawn L. Hervey-Jumper(Shawn.Hervey-Jumper@ucsf.edu)

Recent work in the field of cancer neuroscience has demonstrated bidirectional interactions between neurons and cancer cells ultimately influencing neural circuit function, tumor growth, and patient survival. In a recent paper published in Cell Research, Xu et al. take a novel approach, identifying a secretory factor-induced central nervous system-mediated increase in peripheral autonomic sympathetic activity that drives tumor–immune cell interactions and tumor progression across multiple cancer types.

https://doi.org/10.1038/s41422-024-00960-1

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