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Z-DNA marks the spot for AIRE

Yael Goldfarb , Jakub Abramson

Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel
* Correspondence: Yael Goldfarb(yael.goldfarb@weizmann.ac.il)Jakub Abramson(jakub.abramson@weizmann.ac.il)

Autoimmune regulator (AIRE) is a unique transcriptional regulator that induces ectopic expression of thousands of tissue-specific genes in the thymus, a step critical for the establishment of immunological tolerance to self. In their recent publication, Fang et al. provide novel mechanistic insights into AIRE’s modus operandi, by highlighting Z-DNA as a key cis-regulatory element, critical for guiding AIRE to its target genes.

https://doi.org/10.1038/s41422-024-00964-x

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