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ILC2s govern sex-differential immunity in skin
Katie L. Flanagan1,2,3,*
1Tasmanian Vaccine Trial Centre, Launceston General Hospital, Launceston, TAS, AustraliaThe mechanisms driving sex differences in immunity are poorly understood and likely vary by body site; thus Chi et al. investigated the mechanistic basis of sex differences in tissue-specific immunity in a recent paper in Science. They focused on the complex network of immune cells in murine skin to demonstrate that an androgen-ILC2-dendritic cell axis drives sex differences in immune homeostasis in the skin that is modulated by sex-differential microbiota.
https://doi.org/10.1038/s41422-024-00972-x