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ILC2s govern sex-differential immunity in skin

Katie L. Flanagan1,2,3,*

1Tasmanian Vaccine Trial Centre, Launceston General Hospital, Launceston, TAS, Australia
2School of Medicine, University of Tasmania, Launceston, TAS, Australia
3School of Health and Biomedical Science, RMIT University, Melbourne, VIC, Australia
* Correspondence: Katie L. Flanagan(katie.flanagan@ths.tas.gov.au)

The mechanisms driving sex differences in immunity are poorly understood and likely vary by body site; thus Chi et al. investigated the mechanistic basis of sex differences in tissue-specific immunity in a recent paper in Science. They focused on the complex network of immune cells in murine skin to demonstrate that an androgen-ILC2-dendritic cell axis drives sex differences in immune homeostasis in the skin that is modulated by sex-differential microbiota.

https://doi.org/10.1038/s41422-024-00972-x

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