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No pain, no gain — how nociceptors orchestrate tissue repair

Pavel Hanč^1,2 , Ulrich H. von Andrian^1,2,*

¹Department of Immunology, Harvard Medical School, Boston, MA, USA
²The Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA
* Correspondence: Ulrich H. von Andrian(uva@hms.harvard.edu)

Pain-sensing peripheral neurons, nociceptors, exert control over many aspects of the immune response through various means, including the secretion of immunomodulatory molecules. Adding to the growing list of such interactions, a recent article by Lu et al. reported that a nociceptive neuropeptide, calcitonin gene-related peptide, induces thrombospondin-1 expression in macrophages and neutrophils, limiting their pro-inflammatory functions and promoting tissue repair after injury.

https://doi.org/10.1038/s41422-024-00979-4

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