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All-in-one Hangzhou Protocol: killing four birds with one stone

Haopeng Wang^1,2,3,†,* , Shizhen Qiu^1,4,† , Mohamad Mohty^5,*

¹School of Life Science and Technology, ShanghaiTech University, Shanghai, China
²State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China
³Shanghai Clinical Research and Trial Center, Shanghai, China
⁴Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⁵Department of Clinical Hematology and Cellular Therapy, Saint-Antoine Hospital, AP-HP, Sorbonne University, and INSERM, Saint-Antoine Research Centre, Paris, France
^†These authors contributed equally: Haopeng Wang, Shizhen Qiu
* Correspondence: Haopeng Wang(wanghp@shanghaitech.edu.cn)Mohamad Mohty(mohamad.mohty@inserm.fr)

In a recent study published in The New England Journal of Medicine, researchers developed an innovative “all-in-one” treatment protocol that combines CD7 chimeric antigen receptor T-cell therapy with subsequent haploidentical hematopoietic stem cell transplantation. This approach significantly advances the treatment of CD7+ hematological malignancies by eliminating the need for myeloablative chemotherapy and immunosuppressants for graft-versus-host disease prophylaxis.

https://doi.org/10.1038/s41422-024-00983-8

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