ADVANCE ONLINE PUBLICATION

RESEARCH HIGHLIGHTS

Tumor microenvironment squeezes out the juice from T cells

Romane Thouenon^1,2 , Grégory Verdeil^1,2,*

¹Department of Oncology UNIL CHUV, University of Lausanne, Vaud, Switzerland
²Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland
* Correspondence: Grégory Verdeil(gregory.verdeil@unil.ch)

Escaping the immune response is a major prerequisite for tumor to emerge and progress, and many different mechanisms are in place within the tumor microenvironment (TME) to reach this aim, including the induction of CD8+ T cell exhaustion. In a recent publication in Cell, Zhang and colleagues showed that biomechanical stress occurring in the TME enforces CD8+T cell exhaustion through the expression of the transcription factor Osr2 that acts as an epigenetic regulator.

https://doi.org/10.1038/s41422-024-00987-4

FULL TEXT | PDF

Browse 681