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Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis

Benoit Viollet^1,* , Bruno Guigas²

¹Université Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France
²Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands
* Correspondence: Benoit Viollet(benoit.viollet@inserm.fr)

The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability, proliferation, and function. Recent discoveries in Cell Research have highlighted the role of the lysosomal pool of AMPK in promoting glutaminolysis during glucose shortage through the activation of a PDZD8-GLS1 axis.

https://doi.org/10.1038/s41422-024-01040-0

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