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Structure and genome editing activity of the novel CRISPR-Cas12o1 effector

Zhiqiang Duan^1,† , Xi Zhang^1,† , Jun-Tao Zhang^2,† , Xingkun Ji^1,† , Ruiheng Liu³ , Ying Chen³ , Shanshan Li³ , Nannan Jia³ , Huizhi Gao³ , Yu Xin³ , Ning Jia^2,4,5,* , Jian-Kang Zhu^1,6,*

¹Institute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China
²Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China
³Bellagen Biotechnology Co. Ltd., Jinan, Shandong, China
⁴Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen, Guangdong, China
⁵Key University Laboratory of Metabolism and Health of Guangdong, Institute for Biological Electron Microscopy, Southern University of Science and Technology, Shenzhen, Guangdong, China
⁶Center for Advanced Bioindustry Technologies, Chinese Academy of Agricultural Sciences, Beijing, China
^†These authors contributed equally: Zhiqiang Duan, Xi Zhang, Jun-Tao Zhang, Xingkun Ji
* Correspondence: Ning Jia(jian@sustech.edu.cn)Jian-Kang Zhu(zhujk@sustech.edu.cn)

https://doi.org/10.1038/s41422-024-01050-y

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