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Encoding immune responses: the moonlighting function of alanyl-tRNA synthetase

Pin Wang^1,* , Xiaoyu Hu^2,3,4,*

¹National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China
²Institute for Immunology, Tsinghua University, Beijing, China
³School of Basic Medical Sciences, Tsinghua University, Beijing, China
⁴Tsinghua-Peking Center for Life Sciences, Beijing, China
* Correspondence: Pin Wang(wangp@immunol.org)Xiaoyu Hu(xiaoyuhu@tsinghua.edu.cn)

The emerging role of L-lactate and L-lactylation has been functionally reported in various biological processes. In a recent Nature paper, Li et al. identified alanyl-tRNA synthetases 1/2 as the sensors of L-lactate and lactyltransferases of L-lactylation, conveying repression of innate immune surveillance.

https://doi.org/10.1038/s41422-024-01055-7

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