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Neoself-antigen presentation in SLE: Mordred’s coronation in Arthur’s absence

Mehrdad Pazhouhandeh¹ , Hongjian Sun¹ , Di Yu^1,2,*

¹Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia
²Ian Frazer Centre for Children’s Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia
* Correspondence: Di Yu(di.yu@uq.edu.au)

In a recent study led by Dr. Hisashi Arase published in Cell, a new mechanism underlying the breakdown of self-tolerance in systemic lupus erythematosus was reported that autoreactive T cells recognize neoself-antigens. Neoself-antigens, encompassing a range of self-molecules, were shown to be presented on major histocompatibility complex class II by non-canonical mechanisms following the downregulation of the invariant chain protein.

https://doi.org/10.1038/s41422-024-01052-w

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