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Beyond housekeeping: a new role of snoRNA in nascent protein secretion

Hao Wu¹ , Chu-Xiao Liu¹ , Ling-Ling Chen^1,2,3,4,*

¹Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
²School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
³School of Life Science and Technology, ShanghaiTech University, Shanghai, China
⁴New Cornerstone Science Laboratory, Shenzhen, Guangdong, China
* Correspondence: Ling-Ling Chen(linglingchen@sibcb.ac.cn)

Although small nucleolar RNAs (snoRNAs) are well-known for guiding 2′-O-methylation and pseudouridine modification on ribosomal RNAs and small nuclear RNAs, their additional functions have remained largely undefined. Liu and colleagues developed snoKARR-seq to map transcriptome-wide snoRNA targets, and discovered an unexpected role of snoRNA: SNORA73 simultaneously binds to the target mRNA and the 7SL RNA of the signal recognition particle to form ternary interactions that facilitate the secretion of the encoded protein.

https://doi.org/10.1038/s41422-024-01070-8

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