ADVANCE ONLINE PUBLICATION

RESEARCH HIGHLIGHTS

Grease, fuel and target — polyunsaturated lipids in metastasis

Annemarie Schwab¹ , Thomas Brabletz^1,2,*

¹Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany
²Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany
* Correspondence: Thomas Brabletz(thomas.brabletz@fau.de)

Metastasis is a multistep process requiring ongoing adaptations of cancer cells. A recent study by Wang et al. published in Cell identified polyunsaturated fatty acids as important players in this process; these lipids support metastatic dissemination and colonization but due to their relevance for ferroptosis also open novel therapeutic windows.

https://doi.org/10.1038/s41422-025-01089-5

FULL TEXT | PDF

Browse 61