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NO-immune privilege for hematopoietic stem cells

Agathe L. Chédeville^1,2 , Simón Méndez-Ferrer^1,2,3,4,5,*

¹Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain
²Instituto de Biomedicina de Sevilla-IBiS (Hospital Universitario Virgen del Rocío/CSIC/ Universidad de Sevilla), Seville, Spain
³Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
⁴Department of Haematology, University of Cambridge, Cambridge, UK
⁵NHS Blood and Transplant, Cambridge, UK
* Correspondence: Simón Méndez-Ferrer(smendez@us.es)

Hematopoietic stem cells (HSCs) are localized in anatomically and functionally distinctive bone marrow (BM) niches that regulate their regenerative functions in hematopoiesis and immunity; yet the cellular and molecular underpinnings of these niches remain incompletely defined. A recent study in Nature highlighted nitric oxide as a regulator of dormant, self-renewing HSCs that reside in immune-privileged vascular niches near the bone surface (endosteal) in the metaphyseal BM.

https://doi.org/10.1038/s41422-025-01087-7

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