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New insights into how parental worms protect their offspring

Chenming Zeng , Eric A. Miska

Department of Biochemistry, University of Cambridge, Cambridge, UK
* Correspondence: Eric A. Miska(eam29@cam.ac.uk)

Parental exposure of Caenorhabditis elegans to pathogens can protect offspring against similar threats, but the bacterial cues and intergenerational signals underlying this response remain poorly understood. A recent study in Cell revealed a novel mechanism of intergenerational protection against natural pathogens, facilitated by the cyanoalanine synthase CYSL-2 and its detoxification intermediate.

https://doi.org/10.1038/s41422-025-01094-8

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