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SPO11 cuts!

Sara Hariri^1,2 , Neil Hunter^1,2,*

¹Howard Hughes Medical Institute, University of California, Davis, CA, USA
²Department of Microbiology & Molecular Genetics, University of California, Davis, CA, USA
* Correspondence: Neil Hunter(nhunter@ucdavis.edu)

During meiosis, SPO11-catalyzed DNA double-strand breaks (DSBs) initiate homologous recombination, which is essential for accurate chromosome segregation and enhances genome diversification. 28 years after its discovery, three new studies report the reconstitution of SPO11-catalyzed DSB formation in vitro.

https://doi.org/10.1038/s41422-025-01093-9

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