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A phytoalexin dismantles bacterial type III injectisome

Manman Zhang¹ , Cheng Li^1,* , Zheng Qing Fu^2,*

¹State Key Laboratory of Green Pesticide, Department of Plant Pathology, College of Agriculture, Guizhou University, Guiyang, Guizhou, China
²Department of Biological Sciences, University of South Carolina, Columbia, SC, USA
* Correspondence: Cheng Li(licheng20070242@126.com)Zheng Qing Fu(zfu@mailbox.sc.edu)

Many Gram-negative bacterial pathogens rely on the secretion system to inject effectors into their host cells, thereby suppressing host immunity and subsequently leading to diseases. In a recent Science paper, Miao et al. identified a plant secondary metabolite that dismantles type III injectisome by targeting the conserved HrcC protein within the secretion apparatus.

https://doi.org/10.1038/s41422-025-01111-w

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