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Phase separation paints Xi with Xist

Thomas C. T. Michaels^1,2,* , Anton Wutz^3,*

¹Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
²Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland
³Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology ETH Hönggerberg, Zurich, Switzerland
* Correspondence: Thomas C. T. Michaels(thomas.michaels@bc.biol.ethz.ch)Anton Wutz(awutz@ethz.ch)

In a recent study, Ding et al. investigated the role of hnRNPK phase separation in mammalian dosage compensation. The study stands out by linking biophysical and biochemical measurements with genetic and cell biological experimentation, providing wide-ranging evidence for specific mechanistic aspects of X chromosome inactivation, while expanding the potential repertoire for phase separation in biology.

https://doi.org/10.1038/s41422-025-01116-5

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