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Pyrimidine synthase CAD deamidates and inactivates p53

Yue Qi^1,† , Zizheng Tan^2,† , Hanyu Chen¹ , Ziqi Xiao² , Liang Zhang¹ , Boxuan Wu² , Chennan Liu² , Yunqian Gao³ , Xueyan Yang¹ , Lingqian Wu⁴ , Lei Lu^2,* , Hongyan Wang^1,2,5,*

¹Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Children’s Hospital, Fudan University, Shanghai, China
²Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China
³Pediatric Translational Medicine Institute, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
⁴The Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics & Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, China
⁵Prenatal Diagnosis Center of Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, Guangzhou, China
^†These authors contributed equally: Yue Qi, Zizheng Tan
* Correspondence: Lei Lu(lulei@fudan.edu.cn)Hongyan Wang(wanghy@fudan.edu.cn)

https://doi.org/10.1038/s41422-025-01112-9

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