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Allogeneic anti-CD19 CAR-T cells induce remission in refractory systemic lupus erythematosus

Chunmei Yang^1,† , Chuanyin Sun^2,† , Binghe Tan^3,4,† , Chao Hu¹ , Liyan Wan² , Chris Wang⁴ , Xiujuan Shi⁴ , Juliang Qin³ , Na Zhang⁴ , Biao Zheng⁴ , Mingyao Liu^3,4,* , Jin Lin^2,* , Bing Du^3,4,* , Hongyan Tong^1,5,6,*

¹Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
²Department of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
³Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China
⁴BRL Medicine Inc., Shanghai, China
⁵Zhejiang Provincial Clinical Research Center for Hematologic Diseases, Hangzhou, Zhejiang, China
⁶Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, Zhejiang, China
^†These authors contributed equally: Chunmei Yang, Chuanyin Sun, Binghe Tan
* Correspondence: Mingyao Liu(myliu@bio.ecnu.edu.cn)Jin Lin(linjinzju@zju.edu.cn)Bing Du(bdu@bio.ecnu.edu.cn)Hongyan Tong(tonghongyan@zju.edu.cn)

https://doi.org/10.1038/s41422-025-01128-1

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