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FUSTer than stress granules: a prion-like domain warns plants of heat

Panagiotis N. Moschou^1,2,3,* , Peter V. Bozhkov^3,*

¹Department of Biology, University of Crete, Heraklion, Greece
²Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece
³Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden
* Correspondence: Panagiotis N. Moschou(panagiotis.moschou@uoc.gr)Peter V. Bozhkov(peter.bozhkov@slu.se)

Although plants are poikilothermic organisms with a limited capacity for thermoregulation, they must still sense temperature to survive adverse conditions. Geng and colleagues show that plants possess a thermosensor protein, FUST1, which phase separates through its prion-like domain in response to rising temperatures, forming condensates that prime stress granule assembly and enhance thermotolerance.

https://doi.org/10.1038/s41422-025-01133-4

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