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Niche-generated taurine is leukemic fuel

Christina Mayerhofer^1,2,3 , David T. Scadden^1,2,3,*

¹Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA
²Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA
³Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
* Correspondence: David T. Scadden(david_scadden@harvard.edu)

A new study by Sharma et al. shows that taurine supplied by osteolineage cells in the bone marrow niche, is hijacked by myeloid leukemia to fuel mTOR-driven glycolysis and resist BCL-2 inhibition. Inhibiting taurine uptake or synthesis in niche cells prevents leukemia progression supporting the idea of a niche-directed therapeutic approach.

https://doi.org/10.1038/s41422-025-01136-1

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