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Gut microbiota fuels clonal hematopoiesis

Francisco Caiado , Markus G. Manz

Department of Medical Oncology and Hematology, University and University Hospital Zürich, Zürich, Switzerland
* Correspondence: Markus G. Manz(markus.manz@usz.ch)

Clonal hematopoiesis of indeterminate potential (CHIP) is a frequent health-debilitating condition resulting from progressive, age-dependent expansion of mutant hematopoietic stem and progenitor cells. In a recent Nature paper, Agarwal et al. show that aging associates with increased gut permeability and consequent higher circulating levels of a microbiota-derived metabolite, ADP-heptose, which upon engaging its receptor ALPK1, favors the clonal expansion of CHIP-mutant hematopoietic stem cells.

https://doi.org/10.1038/s41422-025-01137-0

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