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CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis

Alberto Hernández-Barranco^1,2,3 , Johanna A. Joyce^1,2,3,4,*

¹Department of Oncology, University of Lausanne, Lausanne, Switzerland
²Ludwig Institute for Cancer Research, Lausanne, Switzerland
³Agora Cancer Research Centre Lausanne, Lausanne, Switzerland
⁴L. Lundin and Family Brain Tumor Research Center, Departments of Oncology and Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
* Correspondence: Johanna A. Joyce(johanna.joyce@unil.ch)

Leptomeningeal metastasis (LM) arises in a specialized central nervous system niche where immune dynamics are poorly understood. Remsik et al. uncover a central role for IFNγ-activated dendritic cells in constraining LM growth, highlighting the need for immune-targeted therapies tailored to this unique compartment.

https://doi.org/10.1038/s41422-025-01144-1

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