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Bridging the gap: how sperm’s core structure explains male infertility

Thibault Legal^1,* , Khanh Huy Bui^1,2,*

¹Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada
²Centre de Recherche en Biologie Structurale, McGill University, Montreal, QC, Canada
* Correspondence: Thibault Legal(thibault.legal@mcgill.ca)Khanh Huy Bui(huy.bui@mcgill.ca)

The central apparatus plays a crucial role in regulating the motility of sperm flagella by coordinating dynein activity and waveform symmetry. A recent study published in Cell Research resolves the in situ structure of the central apparatus in mouse sperm using cryo-electron tomography, builds an atomic model with AlphaFold, and reveals the structural and functional roles of the bridge protein CFAP47, linking its disruption to novel mutations identified in asthenozoospermic patients.

https://doi.org/10.1038/s41422-025-01150-3

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