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Too sweet to be savory: how fructose elicits microglia-driven disturbance of neurodevelopment

Maximilian Fliegauf^1,2 , Marco Prinz^1,3,*

¹Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany
²Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg, Germany
³CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany
* Correspondence: Marco Prinz(marco.prinz@uniklinik-freiburg.de)

In a pivotal study, Wang and colleagues reveal how early life high fructose exposure disrupts neurodevelopment. The publication uncovers the GLUT5-HK2 axis by which excessive fructose exposure during postnatal development impairs physiological microglial pruning.

https://doi.org/10.1038/s41422-025-01148-x

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