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Neutrophil maturation holds the secret to human tumor suppression

Bianca Calí^1,2 , Andrea Alimonti^1,2,3,4,5,*

¹Institute of Oncology Research (IOR), Bellinzona, Switzerland
²Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland
³Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
⁴Department of Medicine, University of Padova, Padova, Italy
⁵Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
* Correspondence: Andrea Alimonti(andrea.alimonti@ior.usi.ch)

While the advent of mass cytometry and single-cell RNA sequencing has undoubtedly enabled high-resolution profiling of neutrophil heterogeneity across developmental and maturation stages, the functional significance of this diversity — particularly in the context of cancer — remains incompletely understood. In a recent Cell Research paper, Liu et al. comprehensively dissected the developmental stages of human neutrophils within the bone marrow and uncovered that human myelocytes and metamyelocytes possess potent immunosuppressive properties and play a critical role in cancer progression.

https://doi.org/10.1038/s41422-025-01160-1

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