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Centromeres as minefields: host–virus warfare

Chin Wei Brian Leung , Fumiko Esashi

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
* Correspondence: Fumiko Esashi(fumiko.esashi@path.ox.ac.uk)

Nuclear cGAS acts as a vital line of defense against DNA virus infections. In a recent Cell paper, Lahaye and colleagues uncover a novel mechanism in which nuclear cGAS detects viral infection, triggered by the amplification of centromeric DNA.

https://doi.org/10.1038/s41422-025-01159-8

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