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Structure and activation mechanism of human sweet taste receptor

Haolan Wang^1,† , Xiao Chen^1,† , Yaxin Dai¹ , Shabareesh Pidathala¹ , Yiming Niu² , Chen Zhao³ , Siyu Li¹ , Liang Wang¹ , Chia-Hsueh Lee^1,*

¹Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
²Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY, USA
³Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA
^†These authors contributed equally: Haolan Wang, Xiao Chen
* Correspondence: Chia-Hsueh Lee(chiahsueh.lee@stjude.org)

https://doi.org/10.1038/s41422-025-01156-x

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