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APOL proteins tune gut immunity via commensal lipid recognition

Shohei Asami , Hiroshi Ohno

Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Tsurumi, Yokohama, Japan
* Correspondence: Shohei Asami(shohei.asami@riken.jp)Hiroshi Ohno(hiroshi.ohno@riken.jp)

In a recent paper published in Nature, Yang and colleagues identified a novel lipid–protein interaction that broadly regulates the behavior of dominant gut bacteria from the Bacteroides taxa. This interaction, in turn, tunes the expression of immune-regulating molecules in intestinal epithelial cells and promotes the expansion of specialized immune cells important for gut health.

https://doi.org/10.1038/s41422-025-01166-9

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