ADVANCE ONLINE PUBLICATION

RESEARCH HIGHLIGHTS

An anti-inflammatory autophagic target in chronic diseases

Prithvi Reddy Akepati^1,2 , Vojo Deretic^2,*

¹Gastroenterology Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA
²Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
* Correspondence: Vojo Deretic(VDeretic@salud.unm.edu)

An optimal duration of inflammation protects against pathogens while a drawn-out inflammatory response is associated with chronic disease. Wang and colleagues propose the WSTF protein, whose autophagic degradation during prolonged inflammation results in a pro-inflammatory environment, as a target for therapeutic augmentation to devise new treatments for chronic inflammatory diseases.

https://doi.org/10.1038/s41422-025-01176-7

FULL TEXT | PDF

Browse 15